This article presents a lossless compression of volumetric medical images with the improved three-dimensional (3-D) set partitioning in hierarchical tree (SPIHT) algorithm that searches on asymmetric trees. The tree structure links wavelet coefficients produced by 3-D reversible integer wavelet transforms. Experiments show that the lossless compression with the improved 3-D SPIHT gives improvement about 42% on average over two-dimensional techniques and is superior to those of prior results of 3-D techniques. In addition, we can easily apply different numbers of decomposition between the transaxial and axial dimensions, which is a desirable function when the coding unit of a group of slices is limited in size.
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